A Guide for Women on Mounjaro, Perimenopause, and Cognitive Wellness
If you’re using injectable medications like Mounjaro (tirzepatide) for weight loss or type 2 diabetes, you’re likely focused on improving your overall well-being, including mental clarity, energy, and mood.
But what about natural brain-boosting supplements like Lion’s Mane mushroom or creatine?
Are they effective? Safe to use alongside weight loss injections? And which is the better option, especially for women in perimenopause or menopause, navigating fatigue, hormonal shifts, and brain fog?
🍄 What Are Mushroom Supplements?
Mushroom nootropics like Lion’s Mane (Hericium erinaceus), Reishi, and Cordyceps are herbal supplements derived from medicinal fungi. Among them, Lion’s Mane has emerged as a frontrunner for brain support.
🌟 Benefits of Lion’s Mane:
- Boosts nerve growth factor (NGF), aiding brain repair and memory
- May improve mild cognitive impairment and support focus
- Reduces anxiety and mood changes, especially in midlife women
🧪 Evidence:
- 🧠 A clinical trial by Mori et al. (2009) found significant cognitive improvements in older adults with mild memory issues who took Lion’s Mane for 16 weeks.
👉 View Study – Phytotherapy Research - 😌 In another study, Nagano et al. (2010) showed reduced anxiety and depression scores in menopausal women.
👉 View Study – Biomedical Research
⚖️ Pros:
- Supports neurogenesis
- May ease mood changes during menopause
- Safe and generally well-tolerated
❗ Cons:
- Takes several weeks to notice changes
- Quality varies between brands
- Fewer large-scale human trials
💪 What is Creatine?
You may know creatine as a gym supplement, but it’s also a powerful brain enhancer, especially useful in times of mental fatigue, stress, and cognitive decline.
🔋 Why Creatine Supports the Brain:
- Increases ATP energy in brain cells
- Enhances short-term memory, reasoning, and focus
- Especially useful for vegetarians, older adults, and women under stress
🧪 Evidence:
- A 2018 meta-analysis by Avgerinos et al. concluded that creatine offers significant cognitive benefits, especially during mental stress or sleep deprivation.
👉 View Study – Psychopharmacology - Rae et al. (2003) found that creatine improved IQ and working memory in young adults.
👉 View Study – Proceedings of the Royal Society B
⚖️ Pros:
- Rapid effects (within 1–2 weeks)
- Low cost and easy to find
- Supports muscle and brain function
❗ Cons:
- Can cause water retention
- Best when combined with resistance training
⚖️ Creatine vs. Lion’s Mane: Which Should You Choose?
| Goal | Best Pick |
|---|---|
| Mental fatigue, fast results | ✅ Creatine |
| Mood, neurogenesis, stress | ✅ Lion’s Mane |
| Menopausal cognitive support | ✅ Both stacked |
💡 Stack Idea:
– Morning: 1000mg Lion’s Mane
– Afternoon or post-workout: 3–5g Creatine Monohydrate
💉 Are They Safe with Mounjaro (Tirzepatide)?
✅ Lion’s Mane:
- No known interactions with Mounjaro
- Generally safe unless you have autoimmune disorders
✅ Creatine:
- No known drug interactions with Mounjaro
- Supports muscle retention and energy during weight loss
👩⚕️ Supplements for Perimenopause & Menopause
Both supplements can help with:
- Brain fog
- Mood swings
- Loss of lean mass
- Memory lapses
| Concern | Helpful Supplement |
|---|---|
| Brain fog, memory | 🍄 Lion’s Mane |
| Fatigue, energy, muscle | 💪 Creatine |
| Long-term brain protection | 🧠 Stack Both |
🛍️ Recommended Brands in the UK
| Product | What’s Good | Link |
|---|---|---|
| Hifas da Terra Lion’s Mane | Fruiting body extract, high purity | Visit Site |
| Dirtea Mushroom Powder | Organic Lion’s Mane + Chaga | Dirtea UK |
| MyProtein Creatine | Budget-friendly, high quality | MyProtein |
| Mind Lab Pro | Nootropic blend with Lion’s Mane | MindLabPro.com |
My Final Thoughts
If you’re on Mounjaro or another weight-loss med, and navigating perimenopause, it makes sense to support your brain and body with something natural, safe, and effective.
- Lion’s Mane: Best for mood, memory, and long-term brain health
- Creatine: Best for quick boosts in energy and mental performance
✔️ No known interactions
✔️ Affordable and evidence-backed
✔️ Useful across weight loss and hormonal changes
Reminder: Always speak to a healthcare provider before adding new supplements to your routine, especially if you’re on medication. That’s why www.TheLondonPharmaClinic.co.uk is the place to ask!
